ABSTRACT
This study was conducted to investigate the effect of sesame oil on serum and hepatic Iipid profile in induced hyperlipidemic rat .Eight forty rats were randomly divided into equal six groups of eight animals each for 30 days as follows: The first group [control] was kept on basal diet and water, the second group was kept on basal diet added to it sesame oil [SSO]5%, the third group was given a basal diet supplemented by SSO10%,the fourth group [hyperlipidemic] ,hyperlipidemia was induced at last two weeks by intra peritoneal injection of Triton WR1339 [200mg/Kg, /three times /week] ,fifth group was fed basal diet +i.p of Triton 200mg/Kg +SSO5%,the six group was kept on basal diet +i.p injection of same dose of Triton +SSO10% . Blood samples were collected and serum was separated for determination of the followings triglycerides, cholesterol, HDL[high density lipioprotin], LDL[low density lipoprotein],VLDL [very low density lipoprotein], ALT[Alanin aminotrancferase],AST[Aspartate aminotransferase],GGT [garnrna glutamyl tranferase], ALP [Alkaline phosphatase] ,hepatic Iipid profile, thyroid hormones and adiponectin hormone. Induction of hyperlipidema resulted in a significant elevation of all parameters except HDL, adiponectin and thyroid hormones not significant decrease compared to control group .supplementation with sesame oil 5% and SSO 10% signaficantly decrease in all serum and hepatic Iipid profile and liver enzymes while HDL ,adiponectin ,thyroid hormones are elevated . Conclusion: SSO 5% was possess a better improving potential for hyperlipidemia, serum glucose, adiponectin, thyroid hormones, hepatic Iipid profile than SSO 10%